General Information

  • ID:  hor002895
  • Uniprot ID:  P11975
  • Protein name:  Neuropeptide I
  • Gene name:  NA
  • Organism:  Cardisoma carnifex (Blue land crab)
  • Family:  NA
  • Source:  animal
  • Expression:  sinus gland
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Cardisoma (genus), Gecarcinidae (family), Grapsoidea (superfamily), Thoracotremata, Eubrachyura, Brachyura (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  RSADGFGRMESLLTSL
  • Length:  16(1-16)
  • Propeptide:  RSADGFGRMESLLTSLRGSAESPAALGEASAAHPLE
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Neuropeptide H is the precursor molecule for neuropeptides C, D, E, F and I, which arise by incomplete proteolysis of neuropeptide H.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P11975-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002895_AF2.pdbhor002895_ESM.pdb

Physical Information

Mass: 200769 Formula: C73H122N22O25S
Absent amino acids: CHIKNPQVWY Common amino acids: LS
pI: 6.49 Basic residues: 2
Polar residues: 6 Hydrophobic residues: 5
Hydrophobicity: -12.5 Boman Index: -3436
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 79.38
Instability Index: 4356.88 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  3298549
  • Title:  Amino acid sequences of neuropeptides in the sinus gland of the land crab Cardisoma carnifex: a novel neuropeptide proteolysis site.